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In the tiny human trials so far it is well tolerated, but the sample sizes are small and selective (this isnt a good representation of either a)
So the real divide isnt proven versus bogus
Moderate changes of the K m app values in combination with the altered k cat app values resulted in decreased apparent catalytic efficiencies of E170A/K for both substrates as compared with the wild-type enzyme and E170D (Fig
Great Circle Mapper: KLW / PAKW - Klawock, Alaska "Alaska Seaplanes Early Fall Schedule" (PDF)
